The role of reciprocal fusions in MLL-r acute leukemia: studying the chromosomal translocation t(4;11).

ABSTRACT: Leukemia patients bearing the t(4;11)(q21;q23) translocations can be divided into two subgroups: those expressing both reciprocal fusion genes, and those that have only the MLL-AF4 fusion gene. Moreover, a recent study has demonstrated that patients expressing both fusion genes have a better outcome than patients that are expressing the MLL-AF4 fusion protein alone. All this may point to a clonal process where the reciprocal fusion gene AF4-MLL could be lost during disease progression, as this loss may select for a more aggressive type of leukemia. Therefore, we were interested in unraveling the decisive role of the AF4-MLL fusion protein at an early timepoint of disease development. We designed an experimental model system where the MLL-AF4 fusion protein was constitutively expressed, whi

SUBMITTER: Wilhelm A 

PROVIDER: S-EPMC8530991 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature