Bone Histomorphometry and ¹⁸F-Sodium Fluoride Positron Emission Tomography Imaging: Comparison Between only Bone Turnover-based and Unified TMV-based Classification of Renal Osteodystrophy.

ABSTRACT: Bone biopsy is the gold standard for characterization of renal osteodystrophy (ROD). However, the classification of the subtypes of ROD based on histomorphometric parameters is not unambiguous and the range of normal values for turnover differ in different publications. ¹⁸F-Sodium Fluoride positron emission tomography (¹⁸F-NaF PET) is a dynamic imaging technique that measures turnover. ¹⁸F-NaF PET has previously been shown to correlate with histomorphometric parameters. In this cross-sectional study, 26 patients on dialysis underwent a ¹⁸F-NaF PET and a bone biopsy. Bone turnover-based classification was assessed using Malluche's historical reference values for normal bone turnover. In unified turnover-mineralization-volume (TMV)-based classifica

SUBMITTER: Aaltonen L 

PROVIDER: S-EPMC8531121 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature