Novel recessive locus for body mass index in childhood asthma.
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ABSTRACT:
SUBMITTER: Lee S
PROVIDER: S-EPMC8531156 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Novel recessive locus for body mass index in childhood asthma.
Lee Sanghun S Lasky-Su Jessica J Won Sungho S Laurie Cecelia C Celedón Juan Carlos JC Lange Christoph C Weiss Scott S Hecker Julian J
Thorax 20210422 12
Most genome-wide association studies of obesity and body mass index (BMI) have so far assumed an additive mode of inheritance in their analysis, although association testing supports a recessive effect for some of the established loci, for example, rs1421085 in <i>FTO</i> In two whole-genome sequencing (WGS) studies of children with asthma and their parents (892 Costa Rican trios and 286 North American trios), we discovered an association between a locus (rs9292139) in <i>LOC102724122</i> and BM ...[more]
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