Single-center versus multi-center biparametric MRI radiomics approach for clinically significant peripheral zone prostate cancer.

ABSTRACT:

Objectives

To investigate a previously developed radiomics-based biparametric magnetic resonance imaging (bpMRI) approach for discrimination of clinically significant peripheral zone prostate cancer (PZ csPCa) using multi-center, multi-vendor (McMv) and single-center, single-vendor (ScSv) datasets.

Methods

This study's starting point was a previously developed ScSv algorithm for PZ csPCa whose performance was demonstrated in a single-center dataset. A McMv dataset was collected, and 262 PZ PCa lesions (9 centers, 2 vendors) were selected to identically develop a multi-center algorithm. The single-center algorithm was then applied to the multi-center dataset (single-multi-validation), and the McMv algorithm was applied to both the multi-center dataset (multi-multi-validation)

SUBMITTER: Bleker J 

PROVIDER: S-EPMC8531183 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature