Thermodynamic stability, in-vitro permeability, and in-silico molecular modeling of the optimal Elaeis guineensis leaves extract water-in-oil nanoemulsion.

ABSTRACT: Nanoemulsion is a delivery system used to enhance bioavailability of plant-based compounds across the stratum corneum. Elaeis guineensis leaves are rich source of polyphenolic antioxidants, viz. gallic acid and catechin. The optimal E. guineensis leaves extract water-in-oil nanoemulsion was stable against coalescence, but it was under significant influence of Ostwald ripening over 90 days at 25 °C. The in-vitro permeability revealed a controlled and sustained release of the total phenolic compounds (TPC) of EgLE with a cumulative amount of 1935.0 ± 45.7 µgcm^-2 after 8 h. The steady-state flux and permeation coefficient values were 241.9 ± 5.7 µgcm^-2 h^-1 and 1.15 ± 0.03 cm.h^-1, respectively. The kinetic release mechanism for TPC of EgLE was best d

SUBMITTER: Romes NB 

PROVIDER: S-EPMC8531315 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature