Quantum chemical insight into the effects of the local electron environment on T₂*-based MRI.

ABSTRACT: T₂* relaxation is an intrinsic magnetic resonance imaging (MRI) parameter that is sensitive to local magnetic field inhomogeneities created by the deposition of endogenous paramagnetic material (e.g. iron). Recent studies suggest that T₂* mapping is sensitive to iron oxidation state. In this study, we evaluate the spin state-dependence of T₂* relaxation using T₂* mapping. We experimentally tested this physical principle using a series of phantom experiments showing that T₂* relaxation times are directly proportional to the spin magnetic moment of different transition metals along with their associated magnetic susceptibility. We previously showed that T₂* relaxation time can detect the oxidation of Fe²⁺. In this p

SUBMITTER: Petronek MS 

PROVIDER: S-EPMC8531323 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature