Pathogenesis of Behcet's Syndrome: Genetic, Environmental and Immunological Factors.

ABSTRACT: Behçet's syndrome (BS) is a rare systemic vasculitis, characterized by a wide range of different clinical involvements and unpredictable phases of recurrence and remission. BS can be described as a multifactorial disease with an incompletely known etiopathogenesis; in fact, though presenting some peculiar features, such as its typical geographic distribution and the strong association with the well-known genetic predisposing factor HLA-B^*51, the cause behind the onset and progression of the disease remains currently not fully understood. Besides genetic HLA and non-HLA predisposing associations and epigenetic influence, environmental factors also play an important role in the pathogenesis of the disease, and among these, infectious agents (both bacterial and viral) and specific

SUBMITTER: Mattioli I 

PROVIDER: S-EPMC8531401 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature