Role of B Cell Profile for Predicting Secondary Autoimmunity in Patients Treated With Alemtuzumab.

ABSTRACT:

Objective

To explore if baseline blood lymphocyte profile could identify relapsing remitting multiple sclerosis (RRMS) patients at higher risk of developing secondary autoimmune adverse events (AIAEs) after alemtuzumab treatment.

Methods

Multicenter prospective study including 57 RRMS patients treated with alemtuzumab followed for 3.25 [3.5-4.21] years, (median [interquartile range]). Blood samples were collected at baseline, and leukocyte subsets determined by flow cytometry. We had additional samples one year after the first cycle of alemtuzumab treatment in 39 cases.

Results

Twenty-two patients (38.6%) developed AIAEs during follow-up. They had higher B-cell percentages at baseline (p=0.0014), being differences mainly due to plasmablasts/plasma cells (PB/PC, p=0.00

SUBMITTER: Walo-Delgado PE 

PROVIDER: S-EPMC8531491 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature