Zyxin Mediates Vascular Repair via Endothelial Migration Promoted by Forskolin in Mice.

ABSTRACT: Background and Purpose: Endothelial repair upon vascular injury is critical for the protection of vessel integrity and prevention of the development of vascular disorders, but the underlying mechanisms remain poorly understood. In this study, we investigated the role of zyxin and its associated cyclic adenosine monophosphate (cAMP) signaling in the regulation of re-endothelialization after vascular injury. Experimental Approach: In zyxin-/- and wild-type mice, wire injury of the carotid artery was carried out, followed by Evans blue staining, to evaluate the re-endothelialization. Mice with endothelium-specific zyxin knockout were used to further determine its role. An in vitro wound-healing assay was performed in primary human endothelial cells (ECs) expressing

SUBMITTER: Kang X 

PROVIDER: S-EPMC8531502 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature