A Novel Antimicrobial Peptide Sparamosin_26-54 From the Mud Crab Scylla paramamosain Showing Potent Antifungal Activity Against Cryptococcus neoformans.

ABSTRACT: Due to the increasing prevalence of drug-resistant fungi and the limitations of current treatment strategies to fungal infections, exploration and development of new antifungal drugs or substituents are necessary. In the study, a novel antimicrobial peptide, named Sparamosin, was identified in the mud crab Scylla paramamosain, which contains a signal peptide of 22 amino acids and a mature peptide of 54 amino acids. The antimicrobial activity of its synthetic mature peptide and two truncated peptides (Sparamosin_1-25 and Sparamosin_26-54) were determined. The results showed that Sparamosin_26-54 had the strongest activity against a variety of Gram-negative bacteria, Gram-positive bacteria and fungi, in particular had rapid fungicidal kinetics (killed 99%

SUBMITTER: Chen YC 

PROVIDER: S-EPMC8531530 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature