γδT Cells Are Required for CD8⁺ T Cell Response to Vaccinia Viral Infection.

ABSTRACT: Vaccinia virus (VV) is the most studied member of the poxvirus family, is responsible for the successful elimination of smallpox worldwide, and has been developed as a vaccine vehicle for infectious diseases and cancer immunotherapy. We have previously shown that the unique potency of VV in the activation of CD8⁺ T cell response is dependent on efficient activation of the innate immune system through Toll-like receptor (TLR)-dependent and -independent pathways. However, it remains incompletely defined what regulate CD8⁺ T cell response to VV infection. In this study, we showed that γδT cells play an important role in promoting CD8⁺ T cell response to VV infection. We found that γδT cells can directly present viral antigens in the context of MHC-I for CD8

SUBMITTER: Dai R 

PROVIDER: S-EPMC8531544 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature