Association Between Estrogen Receptors and GATA3 in Bladder Cancer: A Systematic Review and Meta-Analysis of Their Clinicopathological Significance.

ABSTRACT:

Background

Estrogen receptors alpha (ERα) and beta (ERβ) and the cooperating protein GATA-binding factor 3 (GATA3) have been implicated in bladder carcinogenesis and tumour progression. GATA3 and ER have been functionally linked in the establishment of luminal fate in breast tissue, but to date their relationship in bladder cancer has not been established. This information will be useful to advance diagnostic and prognostic markers.

Aim

To determine the relationship between the expression of ERα, ERβ and GATA3 in bladder cancer, disclose their prognostic and diagnostic value and their association with clinicopathological characteristics.

Methods

A comprehensive literature search in PubMed database was performed for all immunohistochemical studies of ERα, ERβ and/or GA

SUBMITTER: Bernardo C 

PROVIDER: S-EPMC8531553 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature