The Candidate Schizophrenia Risk Gene Tmem108 Regulates Glucose Metabolism Homeostasis.

ABSTRACT:

Background

Schizophrenia (SCZ) is a severe psychiatric disease affected by genetic factors and environmental contributors, and premorbid abnormality of glucose metabolism is one of the SCZ characteristics supposed to contribute to the disease's pathological process. Transmembrane protein 108 (Tmem108) is a susceptible gene associated with multiple psychiatric diseases, including SCZ. Moreover, Tmem108 mutant mice exhibit SCZ-like behaviors in the measurement of sensorimotor gating. However, it is unknown whether Tmem108 regulates glucose metabolism homeostasis while it involves SCZ pathophysiological process.

Results

In this research, we found that Tmem108 mutant mice exhibited glucose intolerance, insulin resistance, and disturbed metabolic homeo

SUBMITTER: Yu J 

PROVIDER: S-EPMC8531597 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature