Development of A Decahedral Nanoenzyme Capable of Overcoming Hypoxia to Facilitate the Iodine-125 Radiosensitization of Esophageal Cancer.

ABSTRACT: Radioisotopes have long been leveraged for internal radiotherapy-mediated cancer treatment. However, such therapeutic approaches are associated with serious side effects, and their efficacy is limited by intratumoral hypoxia. Herein, we prepared a folic acid-decorated palladium decahedral platform capable of enhancing the radiotherapeutic efficacy of iodine-125 (¹²⁵I) seed treatment. This decahedral nanoenzyme was able to target tumor regions and catalyze the conversion of intracellular H₂O₂ to O₂, thereby alleviating hypoxia within the tumor microenvironment. In addition, palladium was hypoxia can be alleviated, on the other hand, palladium was able to enhance the radiotherapeutic energy deposition within tumor tissues. The results of this analy

SUBMITTER: Jiao D 

PROVIDER: S-EPMC8531641 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature