Association Between Serum Carcinoembryonic Antigen Levels at Different Perioperative Time Points and Colorectal Cancer Outcomes.

ABSTRACT:

Background

Whether elevated postoperative serum carcinoembryonic antigen (CEA) levels are prognostic in patients with stage II colorectal cancer (CRC) remains controversial.

Patients and methods

Primary and sensitivity analysis populations were obtained from a retrospective, multicenter longitudinal cohort including consecutive patients without neoadjuvant treatment undergoing curative resection for stage I-III CRC. Serum CEA levels before (CEA_pre-m1) and within 1 (CEA_post-m1), 2-3 (CEA_post-m2-3), and 4-6 months (CEA_post-m4-6) after surgery were obtained, and their associations with recurrence-free survival (RFS) and overall survival (OS) were assessed using Cox regression. Sensitivity and subgroup analyses were performed.

Resul

SUBMITTER: Li Z 

PROVIDER: S-EPMC8531644 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature