Drug Repurposing for Alzheimer's Disease Based on Protein-Protein Interaction Network.

ABSTRACT: Alzheimer's disease (AD) is known as a critical neurodegenerative disorder. It worsens as symptoms concerning dementia grow severe over the years. Due to the globalization of Alzheimer's disease, its prevention and treatment are vital. This study proposes a method to extract substantial gene complexes and then introduces potential drugs in Alzheimer's disease. To this end, a protein-protein interaction (PPI) network was utilized to extract five meaningful gene complexes functionally interconnected. An enrichment analysis to introduce the most important biological processes and pathways was accomplished on the obtained genes. The next step is extracting the drugs related to AD and introducing some new drugs which may be helpful for this disease. Finally, a complete network including all the

SUBMITTER: Soleimani Zakeri NS 

PROVIDER: S-EPMC8531773 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature