Serotonin Deficiency Is Associated With Delayed Gastric Emptying.

ABSTRACT:

Background & aims

Gastrointestinal (GI) motility is regulated by serotonin (5-hydroxytryptamine [5-HT]), which is primarily produced by enterochromaffin (EC) cells in the GI tract. However, the precise roles of EC cell-derived 5-HT in regulating gastric motility remain a major point of conjecture. Using a novel transgenic mouse line, we investigated the distribution of EC cells and the pathophysiologic roles of 5-HT deficiency in gastric motility in mice and humans.

Methods

We developed an inducible, EC cell-specific Tph1^CreERT2/+ mouse, which was used to generate a reporter mouse line, Tph1-tdTom, and an EC cell-depleted line, Tph1-DTA. We examined EC cell distribution, morphology, and subpopulations in reporter mice. GI motility was measured in vivo and ex vivo

SUBMITTER: Wei L 

PROVIDER: S-EPMC8532026 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature