Ontology highlight
ABSTRACT:
SUBMITTER: Huberman AD
PROVIDER: S-EPMC8532044 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Huberman Andrew D AD Manu Mihai M Koch Selina M SM Susman Michael W MW Lutz Amanda Brosius AB Ullian Erik M EM Baccus Stephen A SA Barres Ben A BA
Neuron 20080801 3
Our understanding of how mammalian sensory circuits are organized and develop has long been hindered by the lack of genetic markers of neurons with discrete functions. Here, we report a transgenic mouse selectively expressing GFP in a complete mosaic of transient OFF-alpha retinal ganglion cells (tOFF-alphaRGCs). This enabled us to relate the mosaic spacing, dendritic anatomy, and electrophysiology of these RGCs to their complete map of projections in the brain. We find that tOFF-alphaRGCs proje ...[more]