The influenza virus RNA polymerase as an innate immune agonist and antagonist.

ABSTRACT: Influenza A viruses cause a mild-to-severe respiratory disease that affects millions of people each year. One of the many determinants of disease outcome is the innate immune response to the viral infection. While antiviral responses are essential for viral clearance, excessive innate immune activation promotes lung damage and disease. The influenza A virus RNA polymerase is one of viral proteins that affect innate immune activation during infection, but the mechanisms behind this activity are not well understood. In this review, we discuss how the viral RNA polymerase can both activate and suppress innate immune responses by either producing immunostimulatory RNA species or directly targeting the components of the innate immune signalling pathway, respectively. Furthermore, we provide a c

SUBMITTER: Elshina E 

PROVIDER: S-EPMC8532088 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature