Porous Silicon-Based Aptasensors: Toward Cancer Protein Biomarker Detection.

ABSTRACT: The anterior gradient homologue-2 (AGR2) protein is an attractive biomarker for various types of cancer. In pancreatic cancer, it is secreted to the pancreatic juice by premalignant lesions, which would be an ideal stage for diagnosis. Thus, designing assays for the sensitive detection of AGR2 would be highly valuable for the potential early diagnosis of pancreatic and other types of cancer. Herein, we present a biosensor for label-free AGR2 detection and investigate approaches for enhancing the aptasensor sensitivity by accelerating the target mass transfer rate and reducing the system noise. The biosensor is based on a nanostructured porous silicon thin film that is decorated with anti-AGR2 aptamers, where real-time monitoring of the reflectance changes enables the detection and quantifi

SUBMITTER: Arshavsky-Graham S 

PROVIDER: S-EPMC8532149 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature