The Contribution of Macrophages in Old Mice to Periodontal Disease.

ABSTRACT: The prevalence of periodontal disease increases with age. Systemic inflammatory dysregulation also increases with age and has been reported to contribute to the myriad of diseases and conditions that become more prevalent with advanced age. As periodontal disease involves a dysregulated host inflammatory response, the age-related inflammatory dysregulation may contribute to the pathogenesis of periodontal disease in aging populations. However, our understanding of what drives the age-related inflammatory dysregulation is limited. Here, we investigate the macrophage and its contribution to periodontal disease in old and young mice using a ligature-induced periodontal disease model. We demonstrate that control old mice present with an aged periodontal phenotype, characterized by increased al

SUBMITTER: Clark D 

PROVIDER: S-EPMC8532239 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature