MIEF1/2 orchestrate mitochondrial dynamics through direct engagement with both the fission and fusion machineries.

ABSTRACT:

Background

Mitochondrial dynamics is the result of a dynamic balance between fusion and fission events, which are driven via a set of mitochondria-shaping proteins. These proteins are generally considered to be binary components of either the fission or fusion machinery, but potential crosstalk between the fission and fusion machineries remains less explored. In the present work, we analyzed the roles of mitochondrial elongation factors 1 and 2 (MIEF1/2), core components of the fission machinery in mammals.

Results

We show that MIEFs (MIEF1/2), besides their action in the fission machinery, regulate mitochondrial fusion through direct interaction with the fusion proteins Mfn1 and Mfn2, suggesting that MIEFs participate in not only fission but also fusion. Elevated levels of

SUBMITTER: Yu R 

PROVIDER: S-EPMC8532385 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature