Ontology highlight
ABSTRACT:
SUBMITTER: Zhong F
PROVIDER: S-EPMC8532448 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Zhong Feisheng F Wu Xiaolong X Yang Ruirui R Li Xutong X Wang Dingyan D Fu Zunyun Z Liu Xiaohong X Wan XiaoZhe X Yang Tianbiao T Fan Zisheng Z Zhang Yinghui Y Luo Xiaomin X Chen Kaixian K Zhang Sulin S Jiang Hualiang H Zheng Mingyue M
Protein & cell 20211022 4
A fundamental challenge that arises in biomedicine is the need to characterize compounds in a relevant cellular context in order to reveal potential on-target or off-target effects. Recently, the fast accumulation of gene transcriptional profiling data provides us an unprecedented opportunity to explore the protein targets of chemical compounds from the perspective of cell transcriptomics and RNA biology. Here, we propose a novel Siamese spectral-based graph convolutional network (SSGCN) model f ...[more]