Post-Stroke Depression in Patients with Large Spontaneous Intracerebral Hemorrhage.

ABSTRACT:

Objectives

To determine factors associated with post-stroke depression (PSD) and relationship between PSD and functional outcomes in spontaneous intracerebral hemorrhage (ICH) using prospective data from a large clinical trial.

Materials and methods

MISTIE III, a randomized, multicenter, placebo-controlled trial, was conducted to determine if minimally invasive surgery with thrombolysis improves outcome compared to standard medical care. Our primary outcome was post-stroke depression at 180 days. Secondary outcomes were change in blinded assessment of modified Rankin Scale (mRS) from 30 to 180 days, and from 180 to 365 days. Logistic regression models were used to assess the relationship between PSD and outcomes.

Results

Among 379 survivors at day 180, 308 completed C

SUBMITTER: Avadhani R 

PROVIDER: S-EPMC8532502 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature