Targeting PirA^vp and PirB^vp Toxins of Vibrio parahaemolyticus with Oilseed Peptides: An In Silico Approach.

ABSTRACT: Acute hepatopancreatic necrosis disease (AHPND), caused by PirA^vp- and PirB^vp-releasing Vibrio parahaemolyticus strains, has resulted in massive mortality in shrimp aquaculture. Excessive use of antibiotics for AHPND management has led to antibiotic resistance, highlighting the urgency to search for alternatives. Using an in silico approach, we aimed to discover PirA^vp/PirB^vp-binding peptides from oilseed meals as alternatives to antibiotics. To search for peptides that remain intact in the shrimp digestive tract, and therefore would be available for toxin binding, we focused on peptides released from tryptic hydrolysis of 37 major proteins from seeds of hemp, pumpkin, rape, sesame, and sunflower. This yielded 8

SUBMITTER: Ong JH 

PROVIDER: S-EPMC8532646 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature