Co-Occurrence of bla_OXA-23 in the Chromosome and Plasmid: Increased Fitness in Carbapenem-Resistant Acinetobacter baumannii.

ABSTRACT: This study aims to explore the co-occurrence of chromosomal and plasmid bla_OXA-23 in carbapenem-resistant A. baumannii (CRAB) and its influence on phenotypes. A total of 11 CRAB isolates containing copies of bla_OXA-23 on the chromosome and plasmid (CO), as well as 18 closely related isolates with bla_OXA-23, located on either the chromosome or plasmid (SI), were selected for the determination of antibiotic susceptibility, virulence phenotype, and characteristic genomic differences. The co-occurrence of bla_OXA-23 on the CRAB chromosome and plasmids did not enhance carbapenem resistance, but trimethoprim/sulfamethoxazole exhibited significantly reduced minimum inhibitory concentrations in CO. CO demonstrated a high

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8532878 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature