The Tardigrade Damage Suppressor Protein Modulates Transcription Factor and DNA Repair Genes in Human Cells Treated with Hydroxyl Radicals and UV-C.

ABSTRACT: The Ramazzottius varieornatus tardigrade is an extremotolerant terrestrial invertebrate with a length of 0.1-1.0 mm. These small animals show an extraordinary tolerance to extreme conditions such as high pressure, irradiation, chemicals and dehydration. These abilities are linked to a recently discovered damage suppressor protein (Dsup). Dsup is a nucleosome-binding protein that avoids DNA damage after X-ray and oxidative stress exposure without impairing cell life in Dsup-transfected animal and plant cells. The exact "protective" role of this protein is still under study. In human cells, we confirmed that Dsup confers resistance to UV-C and H2O2 exposure compared to untransfected cells. A different transcription factor activation was also observed. In addition, a different expression of e

SUBMITTER: Ricci C 

PROVIDER: S-EPMC8533384 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature