Endocardial Endothelial Dysfunction and Unknown Polymorphic Composite Accumulation in Heart Failure.

ABSTRACT: The accumulation of unknown polymorphic composites in the endocardium damages the endocardial endothelium (EE). However, the composition and role of unknown polymorphic composites in heart failure (HF) progression remain unclear. Here, we aimed to explore composite deposition during endocardium damage and HF progression. Adult male Sprague-Dawley rats were divided into two HF groups-angiotensin II-induced HF and left anterior descending artery ligation-induced HF. Heart tissues from patients who had undergone coronary artery bypass graft surgery (non-HF) and those with dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM) were collected. EE damage, polymorphic unknown composite accumulation, and elements in deposits were examined. HF progression reduced the expression of CD31 in t

SUBMITTER: Kuo HF 

PROVIDER: S-EPMC8533412 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature