Insight into the Lubrication and Adhesion Properties of Hyaluronan for Ocular Drug Delivery.

ABSTRACT: Hyaluronan (HA) is widely used for eye drops as lubricant to counteract dry eye disease. High and low molecular weight HA are currently used in ophthalmology. However, a large portion of the current literature on friction and lubrication addresses articular (joint) cartilage. Therefore, eye drops compositions based on HA and its derivatized forms are extensively characterized providing data on the tribological and mucoadhesive properties. The physiochemical properties are investigated in buffers used commonly in eye drops formulations. The tribological investigation reveals that amphiphilic HA-C12 decreases the friction coefficient. At the same time, the combination of trehalose/HA or HAC12 enhances up to eighty-fold the mucoadhesiveness. Thus, it is predicted a prolonged residence time on

SUBMITTER: Cernohlavek M 

PROVIDER: S-EPMC8533502 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature