Metabolic and Transcriptional Adaptations Improve Physical Performance of Zebrafish.

ABSTRACT: Obesity is a worldwide public health problem with increasing prevalence and affects 80% of diabetes mellitus type 2 cases. Zebrafish (Danio rerio) is an established model organism for studying obesity and diabetes including diabetic microvascular complications. We aimed to determine whether physical activity is an appropriate tool to examine training effects in zebrafish and to analyse metabolic and transcriptional processes in trained zebrafish. A 2- and 8-week experimental training phase protocol with adult zebrafish in a swim tunnel system was established. We examined zebrafish basic characteristics before and after training such as body weight, body length and maximum speed and considered overfeeding as an additional parameter in the 8-weeks training protocol. Ultimately, the effects o

SUBMITTER: Heinkele FJ 

PROVIDER: S-EPMC8533608 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature