The Role of the C-Terminal Lysine of S100P in S100P-Induced Cell Migration and Metastasis.

ABSTRACT: S100P protein is a potent inducer of metastasis in a model system, and its presence in cancer cells of patients is strongly associated with their reduced survival times. A well-established Furth Wistar rat metastasis model system, methods for measuring cell migration, and specific inhibitors were used to study pathways of motility-driven metastasis. Cells expressing C-terminal mutant S100P proteins display markedly-reduced S100P-driven metastasis in vivo and cell migration in vitro. These cells fail to display the low focal adhesion numbers observed in cells expressing wild-type S100P, and the mutant S100P proteins exhibit reduced biochemical interaction with non-muscle myosin heavy chain isoform IIA in vitro. Extracellular inhibitors of the S100P-dependent plasminogen activation pathway r

SUBMITTER: Ismail TM 

PROVIDER: S-EPMC8533620 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature