Neuron-Derived Extracellular Vesicles Modulate Microglia Activation and Function.

ABSTRACT: Microglia act as the immune cells of the central nervous system (CNS). They play an important role in maintaining brain homeostasis but also in mediating neuroimmune responses to insult. The interactions between neurons and microglia represent a key process for neuroimmune regulation and subsequent effects on CNS integrity. However, the molecular mechanisms of neuron-glia communication in regulating microglia function are not fully understood. One recently described means of this intercellular communication is via nano-sized extracellular vesicles (EVs) that transfer a large diversity of molecules between neurons and microglia, such as proteins, lipids, and nucleic acids. To determine the effects of neuron-derived EVs (NDEVs) on microglia, NDEVs were isolated from the culture supernatant o

SUBMITTER: Peng H 

PROVIDER: S-EPMC8533634 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature