Upregulation of cathepsin L gene under mild cold conditions in young Japanese male adults.

ABSTRACT:

Background

Physiological thermoregulatory systems in humans have been a key factor for adaptation to local environments after their exodus from Africa, particularly, to cold environments outside Africa. Recent studies using high-throughput sequencing have identified various genes responsible for cold adaptation. However, the molecular mechanisms underlying initial thermoregulation in response to acute cold exposure remain unclear. Therefore, we investigated transcriptional profiles of six young Japanese male adults exposed to acute cold stress.

Methods

In a climatic chamber, the air temperature was maintained at 28°C for 65 min and was then gradually decreased to 19°C for 70 min. Saliva samples were obtained from the subjects at 28°C before and after 19°C cold exposure and w

SUBMITTER: Yasukochi Y 

PROVIDER: S-EPMC8533667 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature