Impact of Epithelial-Mesenchymal Transition on the Immune Landscape in Breast Cancer.

ABSTRACT: The impact of epithelial-mesenchymal transition (EMT) signature on the immune infiltrate present in the breast cancer tumor microenvironment (TME) is still poorly understood. Since there is mounting interest in the use of immunotherapy for the treatment of subsets of breast cancer patients, it is of major importance to understand the fundamental tumor characteristics which dictate the inter-tumor heterogeneity in immune landscapes. We aimed to assess the impact of EMT-related markers on the nature and magnitude of the inflammatory infiltrate present in breast cancer TME and their association with the clinicopathological parameters. Tissue microarrays were constructed from 144 formalin-fixed paraffin-embedded invasive breast cancer tumor samples. The protein expression patterns of Snail, Tw

SUBMITTER: Khadri FZ 

PROVIDER: S-EPMC8533811 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature