When Order Meets Disorder: Modeling and Function of the Protein Interface in Fuzzy Complexes.

ABSTRACT: The degree of proteins structural organization ranges from highly structured, compact folding to intrinsic disorder, where each degree of self-organization corresponds to specific functions: well-organized structural motifs in enzymes offer a proper environment for precisely positioned functional groups to participate in catalytic reactions; at the other end of the self-organization spectrum, intrinsically disordered proteins act as binding hubs via the formation of multiple, transient and often non-specific interactions. This review focusses on cases where structurally organized proteins or domains associate with highly disordered protein chains, leading to the formation of interfaces with varying degrees of fuzziness. We present a review of the computational methods developed to provide

SUBMITTER: Sacquin-Mora S 

PROVIDER: S-EPMC8533853 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature