Noncontact Optical Measurement of Aqueous Humor Glucose Levels and Correlation with Serum Glucose Levels in Rabbit.

ABSTRACT: The noninvasive measurement of serum glucose levels has been investigated for the monitoring of blood sugar control in diabetes. In our study, we aimed to develop a novel noncontact glucometer (NCGM) utilizing an optical approach to measure the intraocular aqueous humor glucose levels in the anterior chamber of rabbit eyes. The NCGM consists of a hybrid optical system that simultaneously measures near-infrared absorption and the polarized rotatory distribution of glucose molecules in the aqueous humor. In vitro optical measurements demonstrated that NCGM measurements had high precision and repeatability for different glucose levels, including 50 mg/dL (14.36%), 100 mg/dL (-4.05%), 200 mg/dL (-5.99%), 300 mg/dL (4.86%), 400 mg/dL (-2.84%), 500 mg/dL (-0.11%), and 600 mg/dL (4.48%). In the r

SUBMITTER: Hwang YS 

PROVIDER: S-EPMC8533889 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature