Possible Mechanisms of Subsequent Neoplasia Development in Childhood Cancer Survivors: A Review.

ABSTRACT: Advances in medicine have improved outcomes in children diagnosed with cancer, with overall 5-year survival rates for these children now exceeding 80%. Two-thirds of childhood cancer survivors have at least one late effect of cancer therapy, with one-third having serious or even life-threatening effects. One of the most serious late effects is a development of subsequent malignant neoplasms (histologically different cancers, which appear after the treatment for primary cancer), which occur in about 3-10% of survivors and are associated with high mortality. In cancers with a very good prognosis, subsequent malignant neoplasms significantly affect long-term survival. Therefore, there is an effort to reduce particularly hazardous treatments. This review discusses the importance of individual

SUBMITTER: Kruseova J 

PROVIDER: S-EPMC8533890 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature