Novel Non-Immunologic Agents for Relapsed and Refractory Multiple Myeloma: A Review Article.

ABSTRACT: Novel treatments are needed to address the lack of options for patients with relapsed or refractory multiple myeloma. Even though immunotherapy-based treatments have revolutionized the field in recent years, offering new opportunities for patients, there is still no curative therapy. Thus, non-immunologic agents, which have proven effective for decades, are still central to the treatment of multiple myeloma, especially for advanced disease. Building on their efficacy in myeloma, the development of proteasome inhibitors and immunomodulatory drugs has been pursued, and has led to the emergence of a novel generation of agents (e.g., carfilzomib, ixazomib, pomalidomide). The use of alkylating agents is decreasing in most treatment regimens, but melflufen, a peptide-conjugated alkylator with a

SUBMITTER: Bobin A 

PROVIDER: S-EPMC8534104 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature