A Recurrent <i>STAT5B^N642H</i> Driver Mutation in Feline Alimentary T Cell Lymphoma.

ABSTRACT: Alimentary lymphomas arising from T cells are rare and aggressive malignancies in humans. In comparison, they represent the most common anatomical form of lymphoma in cats. Due to the low prevalence in humans, the underlying pathomechanism for these diseases is poorly characterised, limiting experimental analysis and therapeutic exploration. To date, activating mutations of the JAK/STAT core cancer pathway and particularly the STAT5B oncoprotein have been identified in human enteropathy-associated T cell lymphoma. Here, we describe a high homology of human and feline STAT3 and STAT5B proteins and strong conservation at the genomic level. Analysis of 42 samples of feline T cell alimentary lymphoma reveals broad activation of STAT3 and STAT5B. Screening for known activating mutations in S

SUBMITTER: Kieslinger M 

PROVIDER: S-EPMC8534107 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature