The Neurobiological Basis of Cognitive Side Effects of Electroconvulsive Therapy: A Systematic Review.

ABSTRACT: Decades of research have consistently demonstrated the efficacy of electroconvulsive therapy (ECT) for the treatment of major depressive disorder (MDD), but its clinical use remains somewhat restricted because of its cognitive side effects. The aim of this systematic review is to comprehensively summarize current evidence assessing potential biomarkers of ECT-related cognitive side effects. Based on our systematic search of human studies indexed in PubMed, Scopus, and Web of Knowledge, a total of 29 studies evaluating patients with MDD undergoing ECT were reviewed. Molecular biomarkers studies did not consistently identify concentration changes in plasma S-100 protein, neuron-specific enolase (NSE), or Aβ peptides significantly associated with cognitive performance after ECT. Importantly,

SUBMITTER: Bassa A 

PROVIDER: S-EPMC8534116 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature