NK Cell Patterns in Idiopathic Inflammatory Myopathies with Pulmonary Affection.

ABSTRACT: Pulmonary affection (PA) is associated with a substantial increase in morbidity and mortality in patients with idiopathic inflammatory myopathies (IIM). However, the underlying immune mechanisms of PA remain enigmatic and prompt deeper immunological analyses. Importantly, the Janus-faced role of natural killer (NK) cells, capable of pro-inflammatory as well as regulatory effects, might be of interest for the pathophysiologic understanding of PA in IIM. To extend our understanding of immunological alterations in IIM patients with PA, we compared the signatures of NK cells in peripheral blood using multi-color flow cytometry in IIM patients with (n = 12, of which anti-synthetase syndrome = 8 and dermatomyositis = 4) or without PA (n = 12). We did not observe any significant differences for B

SUBMITTER: Pawlitzki M 

PROVIDER: S-EPMC8534165 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature