Detection of Human Cholangiocarcinoma Markers in Serum Using Infrared Spectroscopy.

ABSTRACT: Cholangiocarcinoma (CCA) is a malignancy of the bile duct epithelium. Opisthorchis viverrini infection is a known high-risk factor for CCA and in found, predominantly, in Northeast Thailand. The silent disease development and ineffective diagnosis have led to late-stage detection and reduction in the survival rate. Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) is currently being explored as a diagnostic tool in medicine. In this study, we apply ATR-FTIR to discriminate CCA sera from hepatocellular carcinoma (HCC), biliary disease (BD) and healthy donors using a multivariate analysis. Spectral markers differing from healthy ones are observed in the collagen band at 1284, 1339 and 1035 cm^-1, the phosphate band (vsPO2-) at 1073 cm^-1

SUBMITTER: Chatchawal P 

PROVIDER: S-EPMC8534168 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature