Kir4.1 Dysfunction in the Pathophysiology of Depression: A Systematic Review.

ABSTRACT: A serotonergic dysfunction has been largely postulated as the main cause of depression, mainly due to its effective response to drugs that increase the serotonergic tone, still currently the first therapeutic line in this mood disorder. However, other dysfunctional pathomechanisms are likely involved in the disorder, and this may in part explain why some individuals with depression are resistant to serotonergic therapies. Among these, emerging evidence suggests a role for the astrocytic inward rectifier potassium channel 4.1 (Kir4.1) as an important modulator of neuronal excitability and glutamate metabolism. To discuss the relationship between Kir4.1 dysfunction and depression, a systematic review was performed according to the PRISMA statement. Searches were conducted across PubMed, Scop

SUBMITTER: Della Vecchia S 

PROVIDER: S-EPMC8534194 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature