Evolving Therapeutic Approaches for Older Patients with Acute Myeloid Leukemia in 2021.

ABSTRACT: Acute myeloid leukemia (AML) in older patients is characterized by unfavorable prognosis due to adverse disease features and a high rate of treatment-related complications. Classical therapeutic options range from intensive chemotherapy in fit patients, potentially followed by allogeneic hematopoietic cell transplantation (allo-HCT), to hypomethylating agents or palliative care alone for unfit/frail ones. In the era of precision medicine, the treatment paradigm of AML is rapidly changing. On the one hand, a plethora of new targeted drugs with good tolerability profiles are becoming available, offering the possibility to achieve a prolonged remission to many patients not otherwise eligible for more intensive therapies. On the other hand, better tools to assess patients' fitness and improvem

SUBMITTER: Urbino I 

PROVIDER: S-EPMC8534216 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature