Precision Oncology of High-Grade Ovarian Cancer Defined through Targeted Sequencing.

ABSTRACT:

Background

We examined whether molecular characterization of high-grade epithelial ovarian cancer can inform the diagnosis and/or identify potential actionable targets.

Methods

All of the consecutively sequenced high-grade ovarian tumours with consent between 2014 until 2019 were included. A total of 274 tumours underwent next generation sequencing using a targeted panel.

Results

Patients with high-grade ovarian epithelial cancer were consented to prospective molecular characterization. Clinical information was extracted from their medical record. Tumour DNA was subjected to sequencing, and selected patients received PARP inhibitor therapy.

Conclusions

Tumours from 274 women were sequenced, including high-grade serous carcinoma (n = 252), clear cell carc

SUBMITTER: Wessman S 

PROVIDER: S-EPMC8534266 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature