Metabolism-Associated Epigenetic and Immunoepigenetic Reprogramming in Liver Cancer.

ABSTRACT: Metabolic reprogramming and epigenetic changes have been characterized as hallmarks of liver cancer. Independently of etiology, oncogenic pathways as well as the availability of different energetic substrates critically influence cellular metabolism, and the resulting perturbations often cause aberrant epigenetic alterations, not only in cancer cells but also in the hepatic tumor microenvironment. Metabolic intermediates serve as crucial substrates for various epigenetic modulations, from post-translational modification of histones to DNA methylation. In turn, epigenetic changes can alter the expression of metabolic genes supporting on the one hand, the increased energetic demand of cancer cells and, on the other hand, influence the activity of tumor-associated immune cell populations. In

SUBMITTER: Fan C 

PROVIDER: S-EPMC8534280 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature