Changes in Protein Structural Motifs upon Post-Translational Modification in Kidney Cancer.

ABSTRACT: Post-translational modification (PTM) leads to conformational changes in protein structure, modulates the biological function of proteins, and, consequently, changes the signature of metabolic transformations and the immune response in the body. Common PTMs are reversible and serve as a mechanism for modulating metabolic trans-formations in cells. It is likely that dysregulation of post-translational cellular signaling leads to abnormal proliferation and oncogenesis. We examined protein PTMs in the blood samples from patients with kidney cancer. Conformational changes in proteins after modification were analyzed. The proteins were analyzed using ultra-high resolution HPLC-MS/MS and structural analysis was performed with the AMBER and GROMACS software packages. Fifteen proteins containing P

SUBMITTER: Tikhonov D 

PROVIDER: S-EPMC8534394 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature