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Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span.

ABSTRACT: Certain plant extracts (PEs) contain bioactive compounds that have antioxidant and lifespan-extending activities on organisms. These PEs play different roles in cellular processes, such as enhancing stress resistance and modulating longevity-defined signaling pathways that contribute to longevity. Here, we report the discovery of PEs that extended chronological life span (CLS) in budding yeast from a screen of 222 PEs. We identified two PEs, the leaf extracts of Manihot esculenta and Wodyetia bifurcata that extended CLS in a dose-dependent manner. The CLS-extending PEs also conferred oxidative stress tolerance, suggesting that these PEs might extend yeast CLS through the upregulation of stress response pathways.

SUBMITTER: Kwong MMY

PROVIDER: S-EPMC8534465 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Identification of Tropical Plant Extracts That Extend Yeast Chronological Life Span.

Kwong Mandy Mun Yee MMY Lee Jee Whu JW Samian Mohammed Razip MR Wahab Habibah A HA Watanabe Nobumoto N Ong Eugene Boon Beng EBB

Cells 20211011 10

Certain plant extracts (PEs) contain bioactive compounds that have antioxidant and lifespan-extending activities on organisms. These PEs play different roles in cellular processes, such as enhancing stress resistance and modulating longevity-defined signaling pathways that contribute to longevity. Here, we report the discovery of PEs that extended chronological life span (CLS) in budding yeast from a screen of 222 PEs. We identified two PEs, the leaf extracts of <i>Manihot esculenta</i> and <i>W ...[more]

PMID: 34685698

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