Clinical Applications of Cell-Scaffold Constructs for Bone Regeneration Therapy.

ABSTRACT: Bone tissue engineering (BTE) is a process of combining live osteoblast progenitors with a biocompatible scaffold to produce a biological substitute that can integrate into host bone tissue and recover its function. Mesenchymal stem cells (MSCs) are the most researched post-natal stem cells because they have self-renewal properties and a multi-differentiation capacity that can give rise to various cell lineages, including osteoblasts. BTE technology utilizes a combination of MSCs and biodegradable scaffold material, which provides a suitable environment for functional bone recovery and has been developed as a therapeutic approach to bone regeneration. Although prior clinical trials of BTE approaches have shown promising results, the regeneration of large bone defects is still an unmet medi

SUBMITTER: Venkataiah VS 

PROVIDER: S-EPMC8534498 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature