Synaptotagmin 13 Is Highly Expressed in Estrogen Receptor-Positive Breast Cancer.

ABSTRACT:

Background

Accumulating evidence indicates tumor-promoting roles of synaptotagmin 13 (SYT13) in several cancers; however, no studies have investigated its expression in breast cancer (BC). This study aimed to clarify the significance of SYT13 in BC.

Methods

SYT13 mRNA expression levels were evaluated in BC cell lines. Polymerase chain reaction (PCR) array analysis was conducted to determine the correlation between expression levels of SYT13 and other tumor-associated genes. Then, the association of SYT13 expression levels in the clinical BC specimens with patients' clinicopathological factors was evaluated. These findings were subsequently validated using The Cancer Genome Atlas (TCGA) database.

Results

Among 13 BC cell lines, estrog

SUBMITTER: Ichikawa T 

PROVIDER: S-EPMC8535095 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature